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The most frequent system-organ class adverse events leading to discontinuation in one to 2.5% of women using NuvaRing in the trials included the following: device-related events (foreign body sensation, coital problems, device expulsion), vaginal symptoms (discomfort/vaginitis/vaginal secretion), headache, emotional lability, and weight gain

(PubMed) Yang B, Fan S, Zhi X, et al

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Ann Med 1998;30:159168

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Assessment of the risk of malignancy in Bethesda III thyroid nodules: a comprehensive review