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A more accurate classification like ERZIAN scoring may allow for better discrimination between different disease phenotypes [2]

Tumor endothelial cells are characterized by a pro-angiogenic phenotype, with high expression of VEGF receptors (VEGFR1 and R2), which pathways support endothelial cell survival and proliferation, and release of matrix metalloproteinases (MMP), involved in the remodeling of the extracellular matrix (ECM) and thus facilitating endothelial cell migration (26, 27)

Intradermal injections of cross-linked HA cause a reduction in wrinkles [11]

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Klein A, Schiffner R, Schiffner-Rohe J, Einsele-Kramer B, Heinlin J, Stolz W, Landthaler M

The question is whether you can have both, and the answer is