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Compared with placebo, the mean between-group differences in SBP were 3.31 mm Hg (95% CI 6.92 to 0.31, P = 0.07) for the SEM 0.5 mg group and 6.29 mm Hg (95% CI 9.91 to 2.66, P =0.0007) for the SEM 1 mg group