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[DOI] [PubMed] [Google Scholar] 59.Giuliano F

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Luo and colleagues highlight many advances in molecular analysis and Spitz tumors, such as amplifications in chromosome 11p unique to a subset of Spitz tumors and a potentially distinct HRAS mutation profile in Spitz nevi [48]

Disrupting this pathwayeither by severing kidney sensory nerves, selectively deleting the angiotensin II type 1a receptor (AT1a) in the subfornical organ (SFO), or using optogenetics to silence the kidney-SFO or SFO-paraventricular nucleus (PVN) connectionsreduces sympathetic output, which in turn diminishes structural damage and functional impairment in the kidneys and heart in these models of CKD and heart failure (Cao et al., 2023)

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