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Short-acting GLP-1 receptor agonists such as exenatide immediate-release (Byetta) and lixisenatide (Adlyxin) must be administered within 60 minutes before meals

GLP-1 receptor activation contributes glucose-dependent insulin secretion and central appetite suppression

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Ice crystals damage the peptide structure through a physical mechanism different from heat damage but equally destructive

What researchers are watching in the remaining trials With seven Phase 3 readouts expected this year, researchers have specific questions they want answered

Semaglutide generic launches in other countries Semaglutide is still under patent in the U.S., but other countries may allow generics sooner due to different patent laws and expiration dates