The best treatment depends on your goals, health history, and your provider recommendations
This effect is not interpreted as direct central satiety center action, but rather as a secondary response to sustained fat reduction, potentially involving improved leptin sensitivity in the setting of leptin resistance [24]
Results When comparing 68 patients on acetazolamide alone to 11 patients on combined therapy with acetazolamide and GLP-1 agonists, no significant differences were found in any of the parameters: papilledema grade, best corrected visual acuity (BCVA), visual field (VF) or OCT RNFL thickness improvements over a 12-month period
Las potenciales explicaciones incluyen diferencias en el tipo de pacientes incluidos, la adherencia al tratamiento del estudio, el tamao muestral, la duracin de la exposicin al frmaco y la activacin del receptor GLP1 con una mayor reduccin de HbA1c con anlogos basados en GLP1 humano de accin ms prolongada que con algunos anlogos de exendina 4 de accin corta
Guinney J, Dienstmann R, Wang X, de Reynies A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot B, Morris JS, Simon I, Gerster S, Fessler E, de Sousa e Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam G, Broom B, Boige V, Laderas T, Salazar R, Gray JW, Tabernero J, Bernards R, Friend S, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S , Vermeulen L, Tejpar S
The therapy remains investigational and unavailable outside clinical trials, and it requires specialized endocrinology monitoring due to risks of pancreatitis and gallbladder complications
