EGCG can regulate autoimmunity by reducing the number of leukocytes and CD8 + T cells, inhibiting the adhesion of T lymphocytes to melanocytes, suppressing inflammatory responses by downregulating TNF-, IFN-, and IL-6, while simultaneously inhibiting the expression of CXCL3, CXCL5, C-FOS, CXCR4, S100B, Rab27A, TGF-Br2 genes and upregulating the expression of PI3k and EGFR genes
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This study links the pathology directly to disturbed glutathione homeostasis and protein folding impairment within the ER during critical stages of brain development
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Scientific studies have led to the identification of powerful compounds called curcuminoids, the best-known of which is curcumin