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In this same study, TYK2 knockdown in EndoC-BH1 and primary human islet cells decreased apoptosis, STAT1 and STAT2 phosphorylation, IFN and CXCL10 secretion, and class I HLA protein expression (67)
In laboratory research environments, IGF-1 is utilised to investigate growth factor signalling pathways, cellular communication networks, and metabolic regulation processes
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