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It has been found that cancer-associated fibroblasts (CAFs) have a greater dependence on Gln than tumor cells do and exhibit greater sensitivity to GLS inhibition ( 3 Regulation of Gln metabolism in tumors 3.1 ncRNAs regulate Gln metabolism ncRNAs play a crucial role in the occurrence and development of tumors

Acylation Amino acids react with acid chloride and acid anhydride in an alkaline medium to form phthaloyl amino acids

Moreover, p53 is known to induce the expression of a number of antioxidant genes that would be predicted to suppress ROS accumulation, and therefore counteract ferroptosis [70]

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