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Suspected adverse effects in retatrutide trial participants should be reported to the trial investigator and via the MHRA Yellow Card scheme

Your provider may need to adjust doses of other diabetes medications when initiating or escalating GLP-1 therapy

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Green BD, Hand KV, Dougan JE, McDonnell BM, Cassidy RS, Grieve DJ: GLP-1 and related peptides cause concentration-dependent relaxation of rat aorta through a pathway involving KATP and cAMP

Published August 4, 2023

Retatrutide improved fasting lipid profiles including triglycerides, very low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol in clinical trials in people with T2D or obesity, while low-density lipoprotein cholesterol was reduced in people with obesity 12,13,28