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Once dihexa binds to the c-Met receptor, intracellular signaling cascades (PI3K/Akt, MAPK/ERK) remain active for several hours even after the peptide is metabolized and excreted

[6]-Gingerol, From Zingiber Officinale, Potentiates GLP-1 Mediated Glucose-Stimulated Insulin Secretion Pathway in Pancreatic -Cells and Increases RAB8/RAB10-Regulated Membrane Presentation of GLUT4 Transporters in Skeletal Muscle to Improve Hyperglycemia in Leprdb/db Type 2 Diabetic Mice

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In first protocol, the male mice were deprived of food from 18:00 (16 h fasting) with free access to water 1 day before the experiment

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