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doi:10.1016/S0005-2736(98)00144-8 106

These drugs are mostly available as injectable formulations, though an oral option (semaglutide/Rybelsus) is also available

However, many patients report adaptation over time as their body settles into a new metabolic set point and clothing habits adjust

By interacting with GLP-1 receptors in the brain, semaglutide GLP-1 helps to curb appetite and promote a sense of fullness, making it easier for individuals to adhere to a reduced-calorie diet

doi: 10.1016/j.celrep.2024.114665 38 AktarTChenJEttelaieRHolmesM

Patients are also counseled on potential side effects and guided step by step through the adjustment period to maximize comfort and results