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Glucagon suppression While semaglutide increases insulin, it simultaneously suppresses glucagon, the hormone that raises blood sugar

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While you don't need to be as surgically precise about fasting around the moment of administration, maintaining stable blood sugar and avoiding large insulin spikes will still allow the peptide to work more effectively in the background

Example: If a patient started therapy at BMI 37 and now has BMI 31 after successful treatment, the provider may attest to the BMI at initiation if documented appropriately

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It supports antioxidant activity, protecting immune cells from oxidative damage