Further analysis was conducted to elucidate the characteristics of gastrointestinal adverse reactions associated with the two dosage forms
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GLP-1 drugs mimic a hormone the body produces after eating, which can decrease appetite and lead to feelings of fulness a major reason people lose weight
Lifestyle factors such as protein intake, resistance training, and sleep hygiene meaningfully shape results
Body composition analyses have shown that both fat mass and lean mass decrease with weight loss, though fat mass accounts for the majority of weight lost
However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)