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Acknowledgements This work was supported by the Canadian Institutes of Health Research (CIHR

Subsequent research has extended these findings to broader metabolic populations, with some studies reporting reductions of up to 20% in abdominal fat over a 6-month research period

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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

EA and its analogs EA represents the first clinical application of GST inhibitors

Aguiar, C