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Longer term safety of dipeptidyl peptidase4 inhibitors in patients with type 2 diabetes mellitus: systematic review and metaanalysis

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Split dosing becomes valuable when single dosing produces inconsistent results, when doses above 400mcg are needed, or when evening administration fits better into lifestyle patterns

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Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects