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Their anti-inflammatory action is essential, since low-grade inflammation is a key factor in the perpetuation of cardiovascular damage in patients with HFpEF, especially in the presence of obesity

Balducci S, Iacobellis G, Parisi L, Di Biase N, Calandriello E, Leonetti F, et al

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All can weaken the immune system and allow under-the-radar infections to gain purchase

It works by activating the melanocortin 4 (MC4) receptor, which helps regulate hunger and appetite