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A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours

On the other hand, a randomized, double-blind, placebo-controlled study carried out in Tanzania which enrolled pneumonia hospitalized children with ages ranging from six to thirty-six months comparing a group supplemented with zinc (daily 25 mg) as an adjunct to antibiotic therapy for pneumonia and the other group received placebo

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However, the combination does present clinical challenges that require careful consideration and monitoring