clinical evidence: How Effective Is Each Treatment
How MSCs May Influence Autism Biology In preclinical models, MSC therapy has been associated with: Reduced neuroinflammation Decreased microglial activation Increased production of neurotrophic factors Enhanced synaptic plasticity Improved neuronal survival In mouse models of autism, MSC treatment has been linked to improvements in social interaction and reductions in repetitive behaviors
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[DOI] [PMC free article] [PubMed] [Google Scholar] 65.Duran R.V., Oppliger W., Robitaille A.M., Heiserich L., Skendaj R., Gottlieb E., Hall M.N
[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Qiu X., Boufaied N., Hallal T., Feit A., de Polo A., Luoma A.M., Alahmadi W., Larocque J., Zadra G., Xie Y., et al
Mechanistically, EPA and DHA integrate into platelet membranes and displace arachidonic acid, thereby shifting the eicosanoid balance toward increased prostacyclin (PGI 2 ) and reduced thromboxane A 2 (TXA 2 ) synthesis (248)
