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Xiao B, Xu Z, Viennois E, et al

By exploiting solvent-exposed amino acid side chains on antibody frameworks, these methods enable precise control over protein orientation during conjugation, thereby facilitating the rational design of bispecific antibodies with optimized spatial arrangements for enhanced activity and stability

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The American Medical Society for Sports Medicine (AMSSM) emphasizes the importance of quality control in regenerative medicine, noting that lack of precise control and biological characterization can impede clinical outcomes and pose safety risks