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That mismatch is what creates the fatigue, prolonged soreness, and performance decline that so many GLP-1 users experience

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They are also used for people living with obesity (defined as a body mass index, or BMI, of 30 or more) or overweight individuals (BMI of 27 or more) who have related health issues like high blood pressure or cholesterol

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Additionally, the proximity of the rectum to the urethra (particularly in women) means that prolonged constipation increases the bacterial load near the urinary opening

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