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Top-line trial numbers: Weight-Loss Endpoints by Dose Cohort (Phase 2, 48 weeks) Mean body-weight reduction from baseline at the 48-week primary endpoint: Secondary endpoint magnitudes at the 12mg cohort: 41% mean reduction in fasting insulin

As of early 2025 data, 11 states covered GLP-1 medications for weight loss under their state employee health plans

Be sure to stick to a calorie-controlled diet and engage in regular exercise to minimise the risk of a plateau or weight gain

Semaglutide has a reported half-life of roughly one week

The Blue Horizon Method: A Structured Approach At Blue Horizon, we advocate for a phased journey

Greenbaum H, Weil C, Chodick G, Shalev V, Eisenberg VH