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All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction

It helps neutralize free radicals, support detoxification, and reduce melanin production, contr

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Free radicals, antioxidant defense systems, and schizophrenia

Bjpsych Open 3(1):611 Tuura RO, Buchmann A, Ritter C, Hase A, Haynes M, Noeske R, Hasler G (2023) Prefrontal glutathione levels in major depressive disorder are linked to a lack of positive affect

The very root of the connection between glutathione and L-citrulline can be found in L-arginine turnover, in which glutathione plays a vital role by stimulating this process