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When cells are exposed to oxidative stress, Nrf2 is released from Keap1 and translocates into the nucleus

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It provides the chemical stickiness required to bind to heavy metals and neutralize the free radicals that cause cellular wear and tear

According to the 2014 World Health Organization criteria, there are five main types of epithelioid OC tissue, among which, epithelial OC is the most prevalent, constituting ~90% of all cases

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