Yap IKS, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK: Urinary metabolic phenotyping differentiates children with autism, from their unaffected siblings and age-matched controls
The activity of CBS is increased by ~23-fold upon s -adenosyl-l-methionine binding to its C-terminal domain
Statistical Analysis All results were expressed in mean SD
Given adenosine's role in energy regulation and neurotransmission, other metabolites involved in cellular metabolism, such as taurine, may also contribute to the disrupted energy balance seen in these conditions
BMJ Publishing Group, Mohseni, Saeid, et al
162,339 In addition, the nuclear export of acetylated FOXOs further inhibits autophagy, highlighting that transcription factor function is profoundly influenced by posttranslational modification mechanisms mediated by epigenetic regulators