Although high mTORC activity is associated with shorter lifespan in multiple species, mTORC also plays important roles in the maintenance of skeletal muscle mass and prevention of atrophy [90] suggesting that mTORC inhibition could have deleterious effects on skeletal muscle
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Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors
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Recently, a methodology termed selective organ targeting (SORT) has been developed, which enables controllable delivery of nucleic acids to target tissues [65]
