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However, human clinical trials were primarily small, observational studies in elderly Russian patients focusing on biomarkers like cortisol, melatonin, and cholesterol

Observational data from patients with type 2 diabetes and concurrent rheumatoid arthritis provide indirect evidence

doi: 10.1159/000053283

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[Abstract] KA treatment: Lidocaine (3%) and KA (2 mg/mL) were infused bilaterally into the LC via delivery cannulas connected to the cannula drug delivery system in a 0.2 L volume per side at a rate of 0.1 L/10 s 30 min after training