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Description

it also activates the GIP (glucose-dependent insulinotropic polypeptide) receptor

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Importantly, preclinical studies demonstrated that the synergistic effect of GIPRAs and GLP-1RAs on body weight requires the GABAergic (GABA refers to gamma-aminobutyric acid) GIPR-expressing neurons in the CNS [21, 28]

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Agents that are as effective at weight reduction in diabetic patients, as well as those which add additional protection against related co-morbiditiesNASH and cardiovascular disease--would be compelling

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