Collectively, these findings suggest broader perturbation of arachidonic acid metabolism and eicosanoid signaling in MMA, supporting the involvement of inflammatory and oxidative stress-related mechanisms in disease pathophysiology
In these mice, administration of tamoxifen allows nuclear transport of the Cre-recombinase resulting in deletion of the loxP-flanked stop sequence and permanent expression of YFP (Figure 1)
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Samples were incubated at 37C and periodically analyzed using Dynamic Light Scattering (DLS)
Chen X, Bahramimehr F, Shahhamzehei N, Fu H, Lin S, Wang H, Li C, Efferth T, Hong C (2024) Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans
Mechanistically, SWT activates the Nrf2/HO-1 pathway, boosts antioxidant enzyme expression such as SOD, and attenuates lipid peroxidation, while simultaneously promoting angiogenesis via the STAT3/HIF-1/VEGF cascade, collectively improving follicular microenvironment and reproductive capacity [161]
