The degradation is cumulative multiple short exposures add up
And patients who are frail or at risk of malnutrition probably require an individualized assessment to see if these medications are safe and appropriate
Marketing for the drug in the US carries warnings for pancreatitis, gallbladder problems (including gallstones), low blood sugar, acute kidney injury, diabetic retinopathy (damage to the eyes retina), increased heart rate, and suicidal behavior or thinking. Saxenda, meanwhile, is an injectable solution in a pre-filled pen specifically aimed at weight management in obese or overweight adult patients with a Body Mass Index (BMI) of 30 to 40 kg/m2 and the presence of at least one weight-related comorbidity, like dysglycemia (pre-diabetes or Type 2 diabetes mellitus), hypertension, dyslipidemia or obstructive sleep apnea
Nature , 351 , 761-764
Shorter telomeres are associated with decreased lifespan
doi:10.1016/B978-0-12-405881-1.00001-X Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M (2013) Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7
