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The Best Time to Take a B12 Injection If you have a big event coming up, such as finals week, a vacation, or a wedding, you might be wondering about the best time to take a B12 shot to ensure you feel the benefits when you need them

The trials used doses ranging from 0.25 mg to 54 mg daily (well above typical protocols) for durations up to 24 weeks

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There are no major side effects that you should expect

It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use