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McPherson S, Hardy T, Dufour JF, et al

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This extended activity supports once-weekly dosing rather than requiring daily or multiple daily administration

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236 found that BRD4 methylation at R179, R181, and R183 residue by protein arginine methyltransferase2/4 (PRMT2/4) is essential to selectively control the transcriptional program by facilitating BRD4 recruitment to histones or chromatin

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