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3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression

The FDA label notes reports of acute kidney injury in patients treated with GLP-1 receptor agonists, predominantly in patients who experienced volume depletion from GI side effects [6]

These drugs work through different mechanismssome depress the central nervous system while others block nerve signals at the muscle level, interrupting the pain-spasm cycle