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Some compounds have strong mechanistic logic but thin clinical evidence

6,24,25 Clinically, this manifests as depressed superior fat compartments with full inferior aspects encroaching on the inferior retaining ligament

They also cant have type 2 diabetes, moderate-to-severe sleep apnea or fatty liver disease because those conditions could already be covered by their drug plan and must have one of three conditions, including a body mass index of 35 or higher

GLP-1 medications should be stopped if pancreatitis develops, and should likely be avoided in anyone with pre-existing gastroparesis

Rehfeld 2018)

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