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Pre-clinical vs Clinical Translation Challenges Concentrations that produce robust in-vitro fibroblast responses may not translate predictably to in-vivo or human contexts

10.1159/000460293 [DOI] [PMC free article] [PubMed] [Google Scholar] 53.Hudock KM, Collins MS, Imbrogno M, et al

Overall, of 3583 genes were obtained using DisGeNET database, whereas the compound IMPHY000797 was found to modulate 31 genes (HDAC1, SOD2, FOXO1, PPARGC1A, UBB, AMPK, IDH2, NTRK2, CREBBP, SIRT3, CDC34, PRKAA2, ATP5F1B, MAP4K4, PRKAA1, CDK1, PDE2A, ALOX5, IGF1R, HSD11B1, PTGS1, RELA, ESRRB, EPHX2, HMGCR, MAP2K1, ADORA1, NTRK1, NTRK3, PRKDC, HIF1A)

Citations Faetani L, et al

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