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Cycle Guidelines Common Cagrilintide Research Cycle Lengths Approach Short cycle Duration 16 weeks Review Point Week 16 Notes Reaches maintenance just as titration completes Approach Standard cycle Duration 26-32 weeks Review Point Week 26 / 32 Notes Matches Phase 2 trial durations Approach Long cycle Duration 68 weeks Review Point Week 68 Notes Matches REDEFINE 1 and REDEFINE 2 endpoints Cycle length is a research planning choice, not a treatment recommendation

All NMR experiments were performed at 298 K on a Bruker Avance III spectrometer operating at a proton frequency of 600.1 MHz

Nat Rev Endocrinol (2018) 14(10):591604

They deferred the role and duration of lifestyle support to the providers clinical discretion