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To address this question, we mutated Tyr110 in the CPYS-motif of ScGrx7 as a candidate residue that might contribute to the glutathione activator site (see Discussion for details) and performed a preliminary study with wild-type ScGrx7 as a control
Levtchenko EN, van Dael CM, de Graaf-Hess AC, Wilmer MJ, van den Heuvel LP, Monnens LA, Blom HJ (2006) Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis
10.1016/S0015-0282(02)02959-X
Administration method depends on experimental design
In patients with autoimmune thyroid disease or on anti-thyroid drug therapy, increased iodine intake can induce hypothyroidism, whereas, in patients with diffuse nodular goitre or latent Graves disease, it can cause hyperthyroidism (176)