Folic acid mediates activation of the pro-oncogene STAT3 via the folate receptor alpha
Common ANA Patterns: : Entire nucleus is diffusely stained Homogeneous Often associated with SLE or drug-induced lupus May also be seen in mixed connective tissue disease (MCTD) : Fine or coarse speckles throughout the nucleus Speckled May be seen in Sjgrens syndrome, systemic sclerosis, and mixed connective tissue disease Fine speckled pattern is often associated with SLE Coarse speckled pattern may indicate MCTD or undifferentiated connective tissue disease : 30-60 uniform speckles distributed in the nucleus Centromere Often associated with limited forms of scleroderma (CREST syndrome) Can also be seen in primary biliary cirrhosis : Staining of the nucleolus only Nucleolar May be seen in scleroderma or polymyositis Also associated with Raynauds phenomenon : Staining around the outer edge of the nucleus Peripheral (Rim) Strongly associated with SLE Can also be seen in autoimmune hepatitis While these patterns can provide clues, they are not definitive for diagnosing specific autoimmune diseases
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