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Many patients experience a reduced appetite, an extra energy boost, and enhanced motivation

( 10.1038/s41574-018-0016-2) [DOI] [PubMed] [Google Scholar] 13.Wysham C, Grimm M, Chen S

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP, Ciccarella A, Calcagnotto A, Mikhael PG, Mentch SJ, Liu J, Ables G, Kirsch DG, Hsu DS, Nichenametla SN, Locasale JW

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Missing doses or varying the time by several hours each day creates peaks and valleys in blood concentration that reduce overall effectiveness and can worsen side effects like nausea