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Keywords Hepatitis B virus, Pro-inflammatory macrophage, Anti-inflammatory macrophage, Immune modulation, Kupffer cells, IL-1beta, Primary cells, Anti-viral Introduction Hepatitis B virus (HBV) chronically infects more than 250 million individuals worldwide and is responsible for more than 800,000 deaths per year by promoting end-stage liver diseases, among which decompensated cirrhosis and hepatocellular carcinoma (HCC) (WHO, July 2020) are prominent

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