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Understanding GLP-1R agonists Mechanism of action GLP-1R agonists mimic the hormone GLP-1 , which regulates: Insulin secretion (increases insulin release in response to glucose)

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In addition, the enteric nervous system (ENS), which is a recognized second brain that can regulate many GI functions independent of CNS action, can also act as an intermediate in relaying gut-derived information to the CNS 25

Other experts are skeptical of this explanation

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Gallwitz B, Witt M, Paetzold G, et al