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IM injection is generally preferred for larger injection volumes (typically 0.5-2mL) as muscle tissue accommodates greater fluid volumes with less discomfort than subcutaneous fat

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The mean participant age was 58, 59% were male, and 79% were White

Moreover, islets extracted from high cholesterol-fed mice showed decreased exendin-4-induced cAMP responses ex vivo (Supplementary Figure 1A), suggesting a direct impact of increased cholesterol levels on GLP-1R signalling

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