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In terms of blood pressure management, GLP-1 RAs modulate the renin-angiotensin-aldosterone system (RAAS), reduce vascular resistance, and improve vascular relaxation, effectively lowering SBP 39,40,41

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Catalase activity initially increased in both groups during early Dox exposure but later became suppressed as cumulative toxicity mounted, with a more profound decline in saline-treated rats

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These changes are essential for achieving and sustaining weight loss