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J Investig Dermatol 126:10361042

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Physical and psychological dependence can develop, particularly with extended use beyond the prescribed short-term period

And so when we look at that what we basically can say is that when you do something to an exponential extent, right from 2 to 5 minutes to 24 hours, seven days a week, you are going to see an exacerbation of any underlying issues

Considering the short half-life of small molecule oral GLP-1 receptor agonists, perhaps approaches to increase the duration of small molecules with a modified-release formulation may lead to improvements in long-term cardiovascular benefits

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