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The number of animals assigned per condition was selected to account for the variability of the examined phenotypes based on pilot experiment and past experience with the animal models (6 animals per experimental condition)

3 HIV-1 primarily infects and destroys the Th1 subset of CD4+ T cells, resulting in compromised production of IL-2, IL-12, and IFN-, and increased susceptibility to opportunistic infections

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J.BickelC.SchnabelR.Genth-ZotzS.TorzewskiM.et al

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Instead of being burned for fuel, these fats accumulate outside the mitochondria, leading to lipotoxicity and further cellular stress