Evidence from the STEP 4 trial In a 68-week randomized withdrawal trial involving adults with obesity or overweight without T2D, continued treatment with semaglutide 2.4 mg once weekly markedly improved long-term weight-loss maintenance
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This activation enhances the antioxidant capacity of dopaminergic neurons and inhibits iron-dependent lipid peroxidation, thereby reducing neuronal loss, improving motor dysfunction, and ultimately delaying PD progression (66)
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