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GLP-1 receptor agonists are licensed in the UK for type 2 diabetes mellitus and specific weight management indications, not for cognitive impairment or dementia GLP-1 receptors are present in brain regions involved in memory and learning, prompting research into potential neuroprotective effects Ongoing clinical trials, including studies of semaglutide in Alzheimer's disease, are examining whether these medications benefit cognitive function Common adverse effects include gastrointestinal symptoms

The GIP receptor adds a second incretin signal that supports insulin sensitivity and appetite regulation

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Research shows that glutathione is the single most protective antioxidant in virtually every tissue of the body

GLP-1 RAs and SGLT2i have different and synergistic effects in CKM syndrome

cited in Mallick at al