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Research indicates that reducing NNMT activity with 5-amino-1MQ alters metabolic processes, promotes changes in adipocyte function, and modulates muscle and nerve physiology

Phase 1b Study of the Safety, Pharmacokinetics, and Disease-Related Outcomes of the Matrix Metalloproteinase-9 Inhibitor Andecaliximab in Patients With Rheumatoid Arthritis

Then samples are analyzed by tandem mass spectrometry (NEM was used as masking agent and added to collecting tubes) and the analytes are quantified using the stable-isotope labelled analogs

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doi: 10.1177/011542650802300116