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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

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However, some research protocols use IM injection near the injury site for localized delivery with potentially higher local concentrations

The Role of Diet While supplements are powerful tools, they work best when supported by a nutrient-dense diet

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