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Lipotoxicity impairs incretin signalling

nutritional deficiencies due to calorie reduction

Women with untreated progesterone deficiency may therefore experience stronger GLP-1 side effects regardless of dose

doi: 10.1038/s41574-019-0176-8 9 MaCAvenellABollandMHudsonJStewartFRobertsonCet al

Chromatographic separation was performed with a two-column system, consisting of a C-18 trap cartridge (300 m ID, 5 mm length) and a picofrit analytical column (75 m ID, 25 cm length) packed in-house with reversed-phase Repro-Sil Pur C18-AQ 3 m resin

6 For adults with heart disease and obesity or overweight, along with a reduced-calorie diet and increased physical activity